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En forgiftning viser sig ofte umiddelbart ved kvalme og opkastninger. En leverskade viser sig derimod fileørst efter nogle dage, med blandt andet påvirkning af hjernen.De aktive stoffer buprenorphin og nalbuphin er midler der virker som de andre syntetiske opioider, Gentlemen de har desuden en modsatrettet virkning, idet de også spærrer for and